AI Security Operations Engineer

The  AI Security Operations Engineer   is responsible for securing, operationalizing, and scaling  AI, Generative AI, and Agentic AI systems  across the enterprise. This role bridges  security architecture, AI governance, and operational security , ensuring AI systems are designed, deployed, and monitored with  security ‑ by ‑ design and runtime assurance .

This role operates as a  hands ‑ on technical leader  and trusted advisor to engineering, AI, and business stakeholders, translating AI risk into actionable security controls without slowing innovation.

Key Responsibilities Lead  security design and operational oversight  for AI, Generative AI, and Agentic AI initiatives across the enterprise

Define and operationalize  AI security frameworks, standards, and review processes  that govern model lifecycle, data usage, and autonomous behavior

Conduct  AI ‑ focused security architecture reviews  and threat modeling to identify and mitigate risks before deployment

Support and monitor   agentic and autonomous AI workflows , ensuring guardrails, accountability, and runtime visibility

Partner with AI leadership and accelerator programs to enable  secure AI adoption at scale

Translate complex AI and cybersecurity risks into  clear business and patient ‑ impact narratives  for senior leadership

Contribute to and evolve  enterprise AI governance programs , aligning with global regulatory expectations (e.g., NIST AI RMF, EU AI Act, privacy frameworks)

Enable continuous improvement of AI security operations through  automation, metrics, and repeatable processes

Required Qualifications Bachelor's Degree

7+ years of experience in  cybersecurity architecture, security engineering, or security operations

Demonstrated expertise securing  cloud, hybrid, and on ‑ prem environments  (AWS, Azure, GCP)

Hands ‑ on experience with  AI/ML security, Generative AI, and Agentic AI concepts

Proven ability to build and scale  enterprise security frameworks  for emerging technologies

Strong background in  threat modeling, risk analysis, and secure solution design

Experience advising and influencing  multiple stakeholders across hundreds of initiatives  annually

Ability to operate independently while shaping strategy and execution

Preferred / Differentiating Skills Experience designing or contributing to  enterprise AI cybersecurity frameworks

Background supporting  AI governance and accelerator programs

Knowledge of  global regulatory and compliance requirements  ( NIST AI RMF, EU AI Act, GDPR, HIPAA, PCI ‑ DSS)

Experience in  life sciences, healthcare, or highly regulated environments

Certifications in  AI governance or cybersecurity  (e.g., AIGP , CISSP, CISM, CISA )

What Success Looks Like AI initiatives move faster because security is  embedded early , not reviewed late

Agentic AI systems are deployed with  clear guardrails, monitoring, and accountability

Security reviews scale across  hundreds of AI and non ‑ AI projects annually  without becoming a bottleneck

Leadership has clear visibility into  AI risk, posture, and readiness

When we put unexpected teams in the same room, we unleash bold thinking with the power to encourage life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from $ 136,044.00 - $204,066.00 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Are you ready to bring new insights and fresh thinking to the table? Fantastic! We have one seat available, and we hope it’s yours. Apply today.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Date Posted 08-Jul-2026 Closing Date 21-Jul-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.